|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
We recently identified two endothelial nitric oxide synthase (eNOS) gene polymorphisms, Glu298Asp and T-786-->C, which are independently associated with coronary spasm. eNOS gene intron 4b/a polymorphism is also reported to be involved in smoking-dependent coronary artery disease.
|
10979242 |
2000 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study, for the first time, suggests an independent association of 894G>T and -786T>C polymorphisms of endothelial nitric oxide synthase gene with coronary artery disease in a Saudi population.
|
20470943 |
2010 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The T allele of the missense Glu(298)Asp endothelial nitric oxide synthase gene polymorphism is associated with coronary heart disease in younger individuals with high atherosclerotic risk profile.
|
11755935 |
2002 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polymorphism Glu298Asp of endothelial nitric oxide (eNOS) gene has been associated with hypertension and coronary artery disease in several populations worldwide, but results are still controversial.
|
20083095 |
2010 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The eNOS -786T>C (odds ratio [OR]; 1.61, 95% confidence interval [CI]; 0.97-2.69), 894G>T (OR; 1.12, 95% CI; 0.65-1.92) and 4a4b (OR; 1.44, 95% CI; 0.87-2.39) polymorphisms were not an independent predisposition factor to coronary artery disease.
|
16842840 |
2007 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The G894T polymorphism on endothelial nitric oxide synthase gene is associated with increased coronary heart disease among Asia population: evidence from a Meta analysis.
|
22417945 |
2012 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The G894T polymorphism in the eNOS gene might influence coronary atherosclerosis rather than ICAS in Koreans.
|
21114134 |
2010 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Glu-298-->Asp (894G-->T) mutation at exon 7 of the endothelial nitric oxide synthase gene and coronary artery disease.
|
10475066 |
1999 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Relationship of the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene and early-onset coronary artery disease.
|
11579346 |
2001 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Relationship between hemorheology and Glu(298)Asp polymorphism of endothelial nitric oxide synthase gene in patients with coronary artery disease.
|
19434512 |
2010 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, a common polymorphism in exon 7 of the eNOS gene (894G-->T) has been reported to be a strong risk factor for coronary artery disease.
|
9731617 |
1998 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
On the basis of present results, it can be concluded that rs1799</span>983 is strongly associated with coronary artery disease in our population and TT genotype of this polymorphism enhanced the risk of coronary artery disease in Pakistani population.
|
25057159 |
2015 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
NO level and endothelial NO synthase gene polymorphism (Glu298Asp) in the patients with coronary artery disease from the Turkish population.
|
15483745 |
2004 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Lack of association of the Glu298Asp polymorphism of endothelial nitric oxide synthase with manifest coronary artery disease, carotid atherosclerosis and forearm vascular reactivity in two Austrian populations.
|
12641536 |
2003 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Lack of association between the Glu298Asp variant of the endothelial nitric oxide synthase gene and the risk of coronary artery disease among Taiwanese.
|
11802531 |
2001 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interactive effects of the ACE DD polymorphism with the NOS III homozygous G849T (Glu298-->Asp) variant in determining endothelial function in coronary artery disease.
|
14989558 |
2003 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the protective HO1 promoter polymorphism correlates with a lower coronary artery plaque burden, whereas the protective ENOS 894 G/T polymorphism seems to favourably influence changes of coronary artery plaque composition during statin therapy, but has no significant correlation to the magnitude of coronary atherosclerosis.
|
22123460 |
2011 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
In Caucasians, association between E298D genotype and risk of coronary heart disease was significantly modified by current smoking status (interaction P=0.013), with the highest risk observed in smokers carrying the variant D298 allele relative to nonsmokers carrying two E298 alleles (adjusted hazard rate ratio 2.07, 95% confidence interval 1.39-3.07).
|
17108813 |
2006 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, we also found that the rs1799983 polymorphism was significantly associated with the susceptibility to peripheral artery disease, whereas the rs2070744 polymorphism was significantly associated with the susceptibility to coronary artery disease in DM patients.
|
30140993 |
2018 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, there was evidence that small studies with more striking results could affect the associations of the Glu298Asp and -786T>C polymorphisms with coronary heart disease.
|
17018701 |
2006 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of eNOS (-786T/C, Intron 4b/4a & 894G/T) and its association with asymptomatic first degree relatives of coronary heart disease patients.
|
27613099 |
2016 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further subgroup analyses according to ethnicity of participants revealed that the rs1799983 and rs2070744 polymorphisms were significantly associated with the risk of coronary artery disease in both Caucasians and Asians, whereas the rs869109213 polymorphism was only associated with the risk of coronary artery disease in Caucasians.
|
30789045 |
2019 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Endothelial nitric oxide synthase G894T gene polymorphism in Chilean subjects with coronary artery disease and controls.
|
16616056 |
2006 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Endothelial nitric oxide synthase (eNOS), which produces NO, plays an important role in the endothelial function under a wide range of physiological conditions. eNOS exon 7 polymorphism (Glu298Asp, G894T) has been considered to influence the risk of coronary artery disease.
|
15595935 |
2005 |
|
rs1799983
|
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effects of eNOS rs1799983 and ACE rs4646994 polymorphisms on the therapeutic efficacy of salvianolate injection in Chinese patients with coronary heart disease.
|
24827774 |
2014 |